Effect of Lactobacillus mali on body weight and glucose homeostasis in diet-induced obese mice
Type 2 diabetes mellitus (T2DM) is a clinical syndrome associated with deficiency of insulin response, which is presumed to be a direct result of the obesity epidemic. Lb. mali, isolated from sugar kefir drink, is a Gram-positive rods (0.5–1 μm in length) and demonstrated an immune-modulating activity in vitro. Certain studies reported that the intestinal microbiota play a pivotal role in conferring diet-induced obesity, insulin resistance and T2DM. Therefore, the purpose of this study was to investigate the effect of potential probiotic strain Lactobacillus (Lb.) mali on the regulating bodyweight gain, body composition and glucose homeostasis using a high-fat diet induced animal model. Results indicated that Lb. mali could altered metabolism in mice model, including significantly loss of bodyweight gain and increase body lean/fat ratio when compared with high fat diet positive control. Oral administration of Lb. mali also showed a better glucose homeostasis regulation in oral glucose tolerance test (OGTT) and area under curve (AUC) test. Additionally, Lb. mali could reduce abdominal and epididymal fat accumulation in three dimensional X-ray photographs measured by Micro-CT System. Above all, the information obtained in this study will provide evidences for considering Lb. mali as a therapeutic agent to protect human or animal modulate obese-relative metabolic syndrome.
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